Radiotherapy activates autophagy to increase CD8+ T cell infiltration by modulating major histocompatibility complex class-I expression in non-small cell lung cancer
Identifieur interne : 000488 ( Main/Exploration ); précédent : 000487; suivant : 000489Radiotherapy activates autophagy to increase CD8+ T cell infiltration by modulating major histocompatibility complex class-I expression in non-small cell lung cancer
Auteurs : Hai Zeng [République populaire de Chine] ; Weijia Zhang [République populaire de Chine] ; Yan Gong [République populaire de Chine] ; Conghua Xie [République populaire de Chine]Source :
- The Journal of International Medical Research [ 0300-0605 ] ; 2019.
Abstract
Radiotherapy is reported to enhance immune responses in cancer, but appropriate doses and mechanisms remain to be investigated. This study explored whether autophagy is involved in the regulation of major histocompatibility complex class I (MHC-I) expression and CD8+ T cell infiltration at different radiation doses.
Non-small cell lung cancer (NSCLC) cell lines A549 and H1975 were exposed to different doses of radiation. The levels of autophagy and MHC-I expression were examined 6 hours after irradiation. The effects of the autophagy inhibitor chloroquine (CQ) on MHC-I expression were also investigated, as well as the relationship between autophagy and MHC-1 expression. Pathological specimens from 69 NSCLC patients were collected, and immunohistochemistry was used to detect MHC-1 expression and CD8+ T cell infiltration in tumors.
Irradiation induced autophagy and MHC-I expression during a single radiation dose from 2 to 20 Gy in a dose-dependent manner. CQ downregulated MHC-I expression. Immunohistochemistry indicated that MHC-I levels were positively correlated with the infiltration of CD8+ T cells in NSCLC cells (R2 = 0.713).
Autophagy induced MHC-I expression and increased CD8+ T cell infiltration. A single radiation dose of 20 Gy induced the strongest CD8+ T cell infiltration.
Url:
DOI: 10.1177/0300060519855595
PubMed: 31187666
PubMed Central: 6726798
Affiliations:
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type="wicri:Area/Main/Exploration">000488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiotherapy activates autophagy to increase CD8<sup>+</sup> T cell infiltration by modulating major histocompatibility complex class-I expression in non-small cell lung cancer</title><author><name sortKey="Zeng, Hai" sort="Zeng, Hai" uniqKey="Zeng H" first="Hai" last="Zeng">Hai Zeng</name><affiliation wicri:level="3"><nlm:aff id="aff1-0300060519855595">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2-0300060519855595">Department of Oncology, The First People’s Hospital of Jingzhou, Jingzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The First People’s Hospital of Jingzhou, Jingzhou</wicri:regionArea><wicri:noRegion>Jingzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Weijia" sort="Zhang, Weijia" uniqKey="Zhang W" first="Weijia" last="Zhang">Weijia Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff2-0300060519855595">Department of Oncology, The First People’s Hospital of Jingzhou, Jingzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The First People’s Hospital of Jingzhou, Jingzhou</wicri:regionArea><wicri:noRegion>Jingzhou</wicri:noRegion></affiliation></author><author><name sortKey="Gong, Yan" sort="Gong, Yan" uniqKey="Gong Y" first="Yan" last="Gong">Yan Gong</name><affiliation wicri:level="3"><nlm:aff id="aff3-0300060519855595">Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xie, Conghua" sort="Xie, Conghua" uniqKey="Xie C" first="Conghua" last="Xie">Conghua Xie</name><affiliation wicri:level="3"><nlm:aff id="aff1-0300060519855595">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4-0300060519855595">Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5-0300060519855595">Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of International Medical Research</title><idno type="ISSN">0300-0605</idno><idno type="eISSN">1473-2300</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>Radiotherapy is reported to enhance immune responses in cancer, but appropriate doses and mechanisms remain to be investigated. This study explored whether autophagy is involved in the regulation of major histocompatibility complex class I (MHC-I) expression and CD8<sup>+</sup> T cell infiltration at different radiation doses.</p></sec><sec><title>Methods</title><p>Non-small cell lung cancer (NSCLC) cell lines A549 and H1975 were exposed to different doses of radiation. The levels of autophagy and MHC-I expression were examined 6 hours after irradiation. The effects of the autophagy inhibitor chloroquine (CQ) on MHC-I expression were also investigated, as well as the relationship between autophagy and MHC-1 expression. Pathological specimens from 69 NSCLC patients were collected, and immunohistochemistry was used to detect MHC-1 expression and CD8<sup>+</sup> T cell infiltration in tumors.</p></sec><sec><title>Results</title><p>Irradiation induced autophagy and MHC-I expression during a single radiation dose from 2 to 20 Gy in a dose-dependent manner. CQ downregulated MHC-I expression. Immunohistochemistry indicated that MHC-I levels were positively correlated with the infiltration of CD8<sup>+</sup> T cells in NSCLC cells (R<sup>2</sup> = 0.713).</p></sec><sec><title>Conclusions</title><p>Autophagy induced MHC-I expression and increased CD8<sup>+</sup> T cell infiltration. 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sortKey="Yan, Z" uniqKey="Yan Z">Z Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, I" uniqKey="Zhang I">I Zhang</name></author><author><name sortKey="Formenti, Sc" uniqKey="Formenti S">SC Formenti</name></author><author><name sortKey="Knisely, J" uniqKey="Knisely J">J. Knisely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romagnoli, Pa" uniqKey="Romagnoli P">PA Romagnoli</name></author><author><name sortKey="Premenko Lanier, Mf" uniqKey="Premenko Lanier M">MF Premenko-Lanier</name></author><author><name sortKey="Loria, Gd" uniqKey="Loria G">GD Loria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geng, J" uniqKey="Geng J">J Geng</name></author><author><name sortKey="Altman, Jd" uniqKey="Altman J">JD Altman</name></author><author><name sortKey="Krishnakumar, S" uniqKey="Krishnakumar S">S Krishnakumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsutani, S" uniqKey="Matsutani S">S Matsutani</name></author><author><name sortKey="Shibutani, M" uniqKey="Shibutani M">M Shibutani</name></author><author><name sortKey="Maeda, K" uniqKey="Maeda K">K Maeda</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Zeng, Hai" sort="Zeng, Hai" uniqKey="Zeng H" first="Hai" last="Zeng">Hai Zeng</name></region><name sortKey="Gong, Yan" sort="Gong, Yan" uniqKey="Gong Y" first="Yan" last="Gong">Yan Gong</name><name sortKey="Xie, Conghua" sort="Xie, Conghua" uniqKey="Xie C" first="Conghua" last="Xie">Conghua Xie</name><name sortKey="Xie, Conghua" sort="Xie, Conghua" uniqKey="Xie C" first="Conghua" last="Xie">Conghua Xie</name><name sortKey="Xie, Conghua" sort="Xie, Conghua" uniqKey="Xie C" first="Conghua" last="Xie">Conghua Xie</name><name sortKey="Zeng, Hai" sort="Zeng, Hai" uniqKey="Zeng H" first="Hai" last="Zeng">Hai Zeng</name><name sortKey="Zhang, Weijia" sort="Zhang, Weijia" uniqKey="Zhang W" first="Weijia" last="Zhang">Weijia Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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